Oh, South Park. The Trey Parker and Matt Stone creation is one of the most ingenious cartoon shows in television history. Characters Kyle, Stan, Cartman and Kenny have become household names over the last two decades thanks to millions who have followed them and other South Park residents as they poke fun at pop culture, the government, trending news events and, last but especially not least, hip-hop.

Throughout South Park's 25 years on air, over a dozen hip-hop artists have appeared on our television screens; "Vote or Die, muthafucka," has become a popular quote during election time, thanks to Diddy. Cartman somehow managed to encourage laughter when he parodied Logic's “1-800-273-8255,” a song detailing suicide prevention. Most recently, Kendrick Lamar's "Humble" was given a nod during a spoof of the track.

Fishsticks now has a double meaning as well, and is now one of the show's more popular episodes thanks to a cartoon Kanye West cameo. The day after it aired in 2009, Kanye shared his sentiments about the show and how it made him reflect on his ego on his blog.

"SOUTH PARK MURDERED ME LAST NIGHT AND IT'S PRETTY FUNNY. IT HURTS MY FEELINGS BUT WHAT CAN YOU EXPECT FROM SOUTH PARK!" 'Ye wrote in all caps. "I ACTUALLY HAVE BEEN WORKING ON MY EGO THOUGH. HAVING THE CRAZY EGO IS PLAYED OUT AT THIS POINT IN MY LIFE AND CAREER. I USE TO USE IT TO BUILD UP MY ESTEEM WHEN NOBODY BELIEVED IN ME.... I JUST WANNA BE A DOPER PERSON WHICH STARTS WITH ME NOT ALWAYS TELLING PEOPLE HOW DOPE I THINK I AM. I NEED TO JUST GET PAST MYSELF. DROP THE BRAVADO AND JUST MAKE DOPE PRODUCT. EVERYTHING IS NOT THAT SERIOUS. AS LONG AS PEOPLE THINK I ACT LIKE A BITCH THIS TYPE OF SHIT WILL HAPPEN TO ME... I'M SURE THE WRITERS AT SOUTH PARK ARE REALLY NICE PEOPLE IN REAL LIFE. THANKS FOR TAKING THE TIME TO DRAW MY CREW. THAT WAS PRETTY FUNNY ALSO!!"

Take a look at every hip-hop related moment—from quick cameos to a full-blown hip-hop album—during South Park's quarter century run-time in the gallery below.

And South Park, keep the laughs comin'.

See 18 of the Funniest Hip-Hop Moments on 'South Park'

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